ROS1 Analyte Control

ROS1 Analyte Control consists of two cores negative and positive for expression of ROS1.

This provides a cost effective means on controlling for ROS1 in immunohistochemistry and fluorescence in situ hybridisation.

ROS1 Negative
ROS1 Positive

ROS1 Introduction

ROS1 is a receptor tyrosine kinase (RTK) encoded by the ROS1 gene. Genetic rearrangements can occur with many different partner genes many of these translocations are associated with a variety of tumors, in particular lung.

Our ROS1 control consists of two cell lines: one with a SLC34A2-ROS1 translocation and resulting fusion protein; the other has no translocation and therefore no ROS1 protein expressed.

Along with our ALK-Lung (EML4-ALK) Analyte Control and PD-L1 Analyte ControlDR, the ROS1 Analyte Control further adds to to our non-small cell lung carcinoma range of biomarker controls. The ROS1 Analyte ControlDR contains a very low expressing cell line. This expressing FIG-ROS1 fusion protein at very low levels and provides subtle staining demonstrating the lower end of detection for these assays.


ROS1 is frequently assessed by immunohistochemistry (IHC) or Next Generation Sequencing (NGS). Initially fluorescence in situ hybridization was the primary test for ROS1 and while still used it has been superseded by IHC and NGS. The latter allows the assessment of a panel of genes and their mutations. However, IHC allows the direct assessment of the fusion protein, the very target the drugs act on.

Related Products

ROS1 Analyte ControlDR

Dynamic range version of our popular ROS1 control

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