ALK Analyte ControlDR
Our ALK Analyte ControlDR consists of four different cell lines with a range of expression for ALK wild type and fusion proteins.
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The ALK Dynamic Range product allows the user to determine if the ALK assay being used is sensitive enough for the use in the detection of EML4-ALK and NPM-ALK.
Assessment
Wild Type (WT) ALK is expressed at low levels and demonstrating it with an ALK assay is indicative of the lower limits of ALK detection. In other words, if this can be demonstrated then the assay is sensitive enough to identify ALK fusions that are often expressed at low levels, such as EML4-ALK in non-small cell lung carcinoma (NSCLC). The cell line in core B of our ALK Dynamic Range product expresses WT ALK and therefore demonstrates the assay’s sensitivity.
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