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ROS1 Dynamic Range Analyte Control

ROS1 Analyte ControlDR is the dynamic range version of our popular ROS1 control, containing an additional cell line with low expression of ROS1. Available now, please contact sales@histocyte.com or visit one of our distributors.

[HCL035]: ROS1 Dynamic Range Analyte Control (2 unstained slides)
[HCL036]: ROS1 Dynamic Range Analyte Control (5 unstained slides)
[HCL037]: ROS1 Dynamic Range Analyte Control (1 cell microarray block)

IHC using Roche SP384 on the Ventana Benchmark Ultra
ROS1DR IHC

ISH using Cytocell ROS1 Plus breakapart
ROS1DR ISH

Introduction
The low expressing glioblastoma cell line contains the FIG-ROS1 fusion, aslso known as GOPC-ROS1. This is an interstitial deletion where the 5' end is lost rather than translocated as seen with SCL34A2-ROS1 where the 5' end resides elsewhere on another chromosome.
Assessment
It is important to note that the FIG-ROS1 is not identified by all FISH assays. Agilent ROS1 FISH gives a false negative demonstrating overlapping signals. FIG-ROS1 is an interstitial deletion that gives rise to a fusion protein hence it is detected by IHC optimised appropriately.
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