ROS1 is a receptor tyrosine kinase (RTK) encoded by the ROS1 gene. Genetic rearrangements can occur with many different partner genes.
Typically, ROS1 translocations or fusions are assessed by FISH. Recently, monoclonal antibodies for IHC that are effective in formalin-fixed, paraffin-embedded specimens, have entered the market. Our ROS1 control consists of two cell lines: one with a SLC34A2-ROS1 translocation and resulting fusion protein; the other has no translocation and therefore no ROS1 protein expressed.
Along with our ALK-Lung (EML4-ALK) Analyte Control and PD-L1 Analyte ControlDR, the ROS1 Analyte Control further adds to to our non-small cell lung carcinoma range of biomarker controls.