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HER2 Dynamic Range Analyte Control

Our specialised HER2 control has a full dynamic range of expression. Enhanced from our multi-purpose breast analyte control to now include a 2+ cell line, this is specifically aimed at those wanting the most reliable, sensitive and accurate control there is for HER2. Available now, please contact sales@histocyte.com or visit one of our distributors.

[HCL026]: HER2 Analyte ControlDR (2 unstained slides)
[HCL027]: HER2 Analyte ControlDR (5 unstained slides)
[HCL028]: HER2 Analyte ControlDR (1 cell microarray block)

HER2 IHC
HER2 Dynamic Range Expression IHC

HER2 ISH
HER2 Dynamic Range Expression FISH

Introduction
Laboratories often struggle for HER2 2+ and sometimes HER2 1+ tissues. Additionally, biomarker expression can vary throughout tissue, often due to a number of factors including, but not limited to:

• Fixation
• Processing artefact
• Heterogeneity of the protein

This means that tissue selected for use as control can vary to the point that it makes its use as a control redundant.

HistoCyte Laboratories cell lines are compact and typically “tissue-like”. In particular the breast ductal carcinoma cells often create “pseudo-acini” producing a more tissue like appearance. The morphology of our cells means that they can tell you more about how they have been treated. It is quite obvious when the morphology is disrupted. Other cell line preparations available in the market, while adequately performing by IHC or FISH, are often sparse and the cellular integrity or morphology is generally poor.

HistoCyte Laboratories cell lines are standardised so are developed and manufactured to provide consistent results throughout the block. This is what differentiates them from tissue controls.

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