ER - Cell Line Control, Dynamic Range

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ER Dynamic Range Analyte Control

Our ER Dynamic Range Analyte Control contains four cores, offering a full range of expression for ER: Negative, Low, Medium, High. Available now, please contact sales@histocyte.com or visit one of our distributors.

[HCL029]: ER Analyte Control^DR (2 unstained slides)

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[HCL030]: ER Analyte Control^DR (5 unstained slides)

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[HCL031]: ER Analyte Control^DR (1 cell microarray block)

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ER IHC

Introduction

Estrogen receptor has long been a target for treatment in breast cancer, with the greatest impact occurring with the introduction of Tamoxifen. Tamoxifen is a selective ER modulator (SERM) as it binds to ER causing dimerization yet does not induce the same recruitment of co-activators as the estrogens do. Newer therapies such as the aromatase inhibitors (AI) have demonstrated a greater effectiveness in both the adjuvant and metastatic setting.